Article

Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage

2024-07-12

Abstract excerpt

Cells must adopt flexible regulatory strategies to make decisions regarding their fate, including differentiation, apoptosis, or survival in the face of various external stimuli. One key cellular strategy that enables these functions is stochastic gene expression programs. However, understanding how transcriptional bursting, and consequently, cell fate, responds to DNA damage on a genome-wide scale poses a challen...

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Literature Corpus work: b2c1dbf2-351b-5ae1-a5a5-750c49bb08bd
DOI: 10.1101/2024.07.10.602845

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