Article

Mutant IDH Inhibitors Induce Lineage Differentiation in IDH-mutant Oligodendroglioma

2021-11-20

Abstract excerpt

<h4>Summary</h4> Recent data showed promising signs of objective tumor responses in subsets of patients with low grade glioma treated with inhibitors of mutant IDH (IDHi) (1). However, the molecular and cellular underpinnings of such responses are not known. Here, we profiled 6,039 transcriptomes by single-cell or single-nucleus RNA-sequencing isolated from three IDH-mutant oligodendroglioma patients with clinical...

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Literature Corpus work: dbbcc6fd-b02b-5ebe-a343-1a594d778741
DOI: 10.1101/2021.11.16.21266364

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