Article

Generation, characterization and drug sensitivities of twelve patient-derived IDH1 mutant glioma cell cultures

2021-04-10

Abstract excerpt

<h4>Background</h4> Mutations of the isocitrate dehydrogenase ( IDH ) gene occur in over 80% of low-grade gliomas and secondary glioblastomas. Despite considerable efforts, endogenous in vitro IDH -mutated glioma models remain scarce. Availability of these models is key for the development of new therapeutic interventions. <h4>Methods</h4> Cell cultures were established from fresh tumor material and expanded...

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Literature Corpus work: d353cae6-5ebe-56cc-b260-4f1bd79fd9ed
DOI: 10.1101/2021.04.09.435131

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