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Integrative multi-modal analysis reveals the contribution of noncoding RNAs to post-treatment progression of IDH-mutant astrocytomas

2025-10-02

Abstract excerpt

IDH-mutant (IDHmut) astrocytomas typically arise as grade 2–3 tumors, but a subset of them progress to grade 4 after treatment, significantly worsening the prognosis. It is unresolved how noncoding RNAs (ncRNAs) contribute to this tumor progression. To characterize ncRNAs’ regulatory roles, we profiled and analyzed the coding and noncoding transcriptomes of matched tumor samples before and after progression to gra...

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Literature Corpus work
649cc85c-0660-5e3c-ba3d-29265291c261
DOI
10.1101/2025.09.30.679694
Open publication

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Integrative multi-modal analysis reveals the contribution of noncoding RNAs to post-treatment progression of IDH-mutant astrocytomasDOI 10.1101/2025.09.30.679694
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