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Article

Shifting the landscape: The role of IDH inhibitors in glioma cell fate.

Cancer cell - 13 May 2024

Giacobetti Skylar A, Fine Howard A

Abstract excerpt

In this issue of Cancer Cell, Spitzer and colleagues demonstrate the role of IDH inhibitors on IDHmutant gliomas in reducing proliferation and enhancing cell differentiation toward an astrocytic-like state, thus altering neurodevelopmental pathways. Despite clinical promise, unresolved questions regarding mechanisms of action and resistance underline the need for further research for treatment optimization.

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Source

Identifiers

PMID: 38579726
DOI: 10.1016/j.ccell.2024.02.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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