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Article

Stalled oligodendrocyte differentiation in IDH-mutant gliomas.

Genome medicine - 13 Apr 2023

Wei Yanfei, Li Guanzhang, Feng Jing, Wu Fan, Zhao Zheng, Bao Zhaoshi, Zhang Wei, Su Xiaodong, Li Jiuyi, Qi Xueling, Duan Zejun, Zhang Yunqiu, Vega Sandra Ferreyra, Jakola Asgeir Store, Sun Yingyu, Carén Helena, Jiang Tao, Fan Xiaolong

Abstract excerpt

BACKGROUND: Roughly 50% of adult gliomas harbor isocitrate dehydrogenase (IDH) mutations. According to the 2021 WHO classification guideline, these gliomas are diagnosed as astrocytomas, harboring no 1p19q co-deletion, or oligodendrogliomas, harboring 1p19q co-deletion. Recent studies report that IDH-mutant gliomas share a common developmental hierarchy. However, the neural lineages and differentiation stages in...

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Identifiers

PMID: 37055795
DOI: 10.1186/s13073-023-01175-6
PMCID: PMC10103394

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