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Affinity‐based selection and the germinal center response

13 Apr 2012

Abstract excerpt

Interactions between B-cell antigen receptors (BCRs) and their ligands have a complexity and variability that is unparalleled within known biology. Each developing B cell undergoes gene rearrangements to generate a BCR encoded by a unique pair of immunoglobulin (Ig) variable region genes, which serves to make the antigen-binding capabilities of primary BCRs incredibly diverse. Further diversification of the BCR...

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PMID: 22500828
DOI: 10.1111/j.1600-065x.2012.01118.x

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