Article

Implicating candidate genes at GWAS signals by leveraging topologically associating domains

2016-11-15

Abstract excerpt

Genome wide association studies (GWAS) have contributed significantly to the understanding of complex disease genetics. However, GWAS only report associated signals and do not necessarily identify culprit genes. As most signals occur in non-coding regions of the genome, it is often challenging to assign genomic variants to the underlying causal mechanism(s). Topologically associating domains (TADs) are primarily c...

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Literature Corpus work: dbb644b6-fa40-5324-9b66-97553aec203c
DOI: 10.1101/087718

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