Article
Systems-level analysis of genome-wide association data.
G3 (Bethesda, Md.) - 1 Jan 2013
Farber Charles R
Abstract excerpt
Genome-wide association studies (GWAS) have emerged as the method of choice for identifying common variants affecting complex disease. In a GWAS, particular attention is placed, for obvious reasons, on single-nucleotide polymorphisms (SNPs) that exceed stringent genome-wide significance thresholds. However, it is expected that many SNPs with only nominal evidence of association (e.g., P < 0.05) truly influence...
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