Article

Mycobacterium abscessus HelR interacts with RNA Polymerase to confer intrinsic rifamycin resistance

2021-05-10

Abstract excerpt

Rifampicin (RIF) constitutes the frontline therapy against M. tuberculosis as well as most slow-growing non-tuberculous mycobacteria (NTM). However, RIF is completely ineffective against M. abscessus despite the absence of mutations in the rifampicin resistance determining region of Mab_rpoB . This has been attributed to the presence of an ADP-ribosyltransferase (Arr) activity that inactivates RIF. Rifabutin (R...

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Literature Corpus work: dba3c4ef-f0a2-5431-a42a-36a83d79f0ff
DOI: 10.1101/2021.05.10.443476

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