Article

Mutations in <i>rv0678</i> confer low-level resistance to benzothiazinone DprE1 inhibitors in <i>M. tuberculosis</i>

2022-06-29

Abstract excerpt

<h4>ABSTRACT</h4> Tuberculosis (TB) is the leading cause of death from any bacterial infection, causing 1.5 million deaths worldwide each year. Due to the emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) there have been significant efforts aimed at developing novel drugs to treat TB. One promising drug target in Mtb is the arabinogalactan biosynthetic enzyme DprE1, and there have been over...

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Literature Corpus work: 6f1b9ad9-c7e6-5e1c-95bb-0cb5a40938f1
DOI: 10.1101/2022.06.29.498178

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