Article

Discovery of inhibitors for bacterial Arr enzymes ADP-ribosylating and inactivating rifamycin antibiotics

2025-02-22

Abstract excerpt

ADP-ribosylation is an enzymatic process where an ADP-ribose moiety is transferred from NAD + to an acceptor molecule. While ADP-ribosylation is well-established as a post-translational modification of proteins, rifamycin antibiotics are its only known small-molecule targets. ADP-ribosylation of rifampicin was first identified in Mycolicibacterium smegmatis, whose Arr enzyme transfers the ADP-ribose moiety to th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e304337a-6e5b-5e1c-9de8-235081f0b10d
DOI: 10.1101/2025.02.20.639278

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discovery of inhibitors for bacterial Arr enzymes ADP-ribosylating and inactivating rifamycin antibioticsDOI 10.1101/2025.02.20.639278Read

Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr.Semantic proximity Read

Genomic epidemiology of rifampicin ADP-ribosyltransferase (Arr) in the Bacteria domainSemantic proximity Read

C25-modified rifamycin derivatives with improved activity against Mycobacterium abscessusSemantic proximity Read

Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessusSemantic proximity Read

The phenotypic landscape of the mycobacterial cellSemantic proximity Read

Inhibition of RNA Polymerase by Rifampicin and Rifamycin-Like MoleculesSemantic proximity Read

Integrative metagenomic and biochemical studies on rifamycin ADP-ribosyltransferases discovered in the sediment microbiome.Semantic proximity Read

Novel Chemical Scaffolds for Inhibition of Rifamycin-Resistant RNA Polymerase Discovered from High-Throughput Screening.Semantic proximity Read

Mycobacterium abscessus HelR interacts with RNA Polymerase to confer intrinsic rifamycin resistanceSemantic proximity Read

Advancement of GyrB Inhibitors for Treatment of Infections Caused by Mycobacterium tuberculosis and Non-tuberculous MycobacteriaSemantic proximity Read

N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.Semantic proximity Read

Ribosomal A site binding pattern differs between Arm methyltransferases from clinical pathogens and a natural producer of aminoglycosides.Semantic proximity Read