Article

MarR-Dependent Transcriptional Regulation of <i>mmpSL5</i> induces Ethionamide Resistance in <i>Mycobacterium abscessus</i>

2022-10-04

Abstract excerpt

Mycobacterium abscessus ( Mabs ) is an emerging non-tuberculosis mycobacterial (NTM) pathogen responsible for a wide variety of respiratory and cutaneous infections that are difficult to treat with standard antibacterial therapy. Mabs has a high degree of both innate and acquired antibiotic resistance to most clinically relevant drugs, including standard anti-mycobacterial agents. Ethionamide (ETH), an inhibitor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 08c08957-23cf-51a0-8e69-f30aaa65ff96
DOI: 10.1101/2022.10.03.510743

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MarR-Dependent Transcriptional Regulation of <i>mmpSL5</i> induces Ethionamide Resistance in <i>Mycobacterium abscessus</i>DOI 10.1101/2022.10.03.510743Read

MarR-Dependent Transcriptional Regulation of mmpSL5 Induces Ethionamide Resistance in Mycobacterium abscessusSemantic proximity Read

Molecular Mechanisms Underlying Antimicrobial Resistance in Mycobacteria.Semantic proximity Read

The TetR Family Transcription Factor MAB_2299c Regulates the Expression of Two Distinct MmpS-MmpL Efflux Pumps Involved in Cross-Resistance to Clofazimine and Bedaquiline in Mycobacterium abscessusSemantic proximity Read

Hierarchy and networks in the transcriptional response of <i>Mycobacterium abscessus</i> to antibioticsSemantic proximity Read

Mutations in <i>rv0678</i> confer low-level resistance to benzothiazinone DprE1 inhibitors in <i>M. tuberculosis</i>Semantic proximity Read

Whole-Transcriptome and -Genome Analysis of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates Identifies Downregulation of ethA as a Mechanism of Ethionamide Resistance.Semantic proximity Read

Mutations in the transcriptional regulator MAB_2885 confer tedizolid and linezolid resistance through the MmpS-MmpL efflux pump MAB_2302-MAB_2303 in Mycobacterium abscessusSemantic proximity Read

Resistance to Thiacetazone Derivatives Active against Mycobacterium abscessus Involves Mutations in the MmpL5 Transcriptional Repressor MAB_4384.Semantic proximity Read

Molecular Mechanisms of Antimicrobial Resistance in Infectious Diseases: Advances in Therapeutic Strategies and Public Health InterventionsSemantic proximity Read

Dissecting erm (41)-Mediated Macrolide-Inducible Resistance in Mycobacterium abscessusSemantic proximity Read

Luciferase reporter mycobacteriophage (TM4:: GeNL ) enables rapid assessment of drug susceptibilities and inducible macrolide resistance in Mycobacterium abscessus complexSemantic proximity Read

High-density transposon mutagenesis in <i>Mycobacterium abscessus</i> identifies an essential penicillin-binding lipo-protein (PBP-lipo) involved in septal peptidoglycan synthesis and antibiotic sensitivitySemantic proximity Read