Article

Multi-tissue spatial transcriptomics reveals biological age hotspots in mouse and human aging

2025-11-26

Abstract excerpt

<h4>ABSTRACT</h4> Aging proceeds heterogeneously across tissues, yet how biological age varies within the spatial architecture of individual organs remains poorly understood. Here, we introduce stAge, a framework that quantifies localized transcriptomic age (tAge) from spatial transcriptomics data in mouse and human samples during natural aging and in response to injury, infection, neurodegeneration, and cancer....

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Literature Corpus work: 8e1d412d-8e01-53cd-be11-f92623dcfbe4
DOI: 10.1101/2025.11.23.689860

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