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Artificial Intelligence Reveals Prognostic TP53 Pathway Alterations in FOLFOX-Treated Early-Onset Colorectal Cancer Among Populations at Risk

2025-10-28

Abstract excerpt

<h4>Background</h4> The incidence of early-onset colorectal cancer (EOCRC; <50 years) continues to rise, with the most rapid increases observed among Hispanic/Latino (H/L) populations. Although the TP53 signaling pathway is a critical driver of colorectal tumorigenesis, its prognostic significance in FOLFOX-treated EOCRC—particularly among H/L patients— remains poorly defined. <h4>Methods</h4> We analyzed 2,515...

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Literature Corpus work
db6cefa9-70bb-5231-a36f-1fb12ed750c6
DOI
10.1101/2025.10.27.25338923
Open publication

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