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Artificial Intelligence Agent: AI-HOPE-TP53 Enables Pathway-Centric Analysis of TP53-Driven Molecular Alterations in Colorectal Cancer Precision Oncology

2025-05-25

Abstract excerpt

<h4>Introduction</h4> Early-onset colorectal cancer (EOCRC) is rising rapidly, especially among populations at risk who experience disproportionate incidence and mortality. The TP53 pathway, frequently altered in CRC, regulates key processes such as DNA repair and apoptosis. Despite its clinical relevance, TP53 dysregulation remains understudied in EOCRC, particularly in populations at risk. Current tools lack su...

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Literature Corpus work
861be35e-41af-5ed9-b355-5229691fa8b5
DOI
10.1101/2025.05.23.25328251
Open publication

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