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Artificial intelligence for precision oncology: AI-HOPE-MAPK uncovers clinically actionable MAPK alterations in colorectal cancer

2025-06-12

Abstract excerpt

<h4>Background</h4> The emergence of early-onset colorectal cancer (EOCRC), particularly among populations with disproportionate health burdens, has exposed critical gaps in our understanding of age– and ancestry-specific oncogenic processes. Aberrations in the mitogen-activated protein kinase (MAPK) pathway—encompassing KRAS, NRAS, BRAF, MAP2K1, MAPK3, and others—are central to tumorigenesis, yet their distributi...

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Literature Corpus work
ccc2f6ec-281d-5e0a-a2d7-47d3cc4b9ad6
DOI
10.1101/2025.06.11.25329446
Open publication

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