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Article

Artificial Intelligence-Enabled Integration Suggests TP53 Pathway Alterations as Prognostic Biomarkers in Populations with Disproportionate Health Burdens.

International journal of molecular sciences - 6 Feb 2026

Diaz Fernando C, Waldrup Brigette, Carranza Francisco G, Manjarrez Sophia, Velazquez-Villarreal Enrique

Abstract excerpt

The incidence of early-onset colorectal cancer (EOCRC; <50 years) continues to increase, with the most rapid rises occurring among Hispanic/Latino (H/L) populations who remain underrepresented in molecular research. Because the TP53 signaling pathway is a key driver of colorectal tumorigenesis, this study aimed to clarify its prognostic significance in FOLFOX-treated EOCRC across ancestry groups. We analyzed 2515...

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Source

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Identifiers

PMID: 41684025
DOI: 10.3390/ijms27031607
PMCID: PMC12898670

Genes

TP53
ATM
CDKN2A
CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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