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Artificial Intelligence-Enabled Precision Medicine Reveals Prognostic Impact of TGF-Beta Pathway Alterations in FOLFOX-Treated Early-Onset Colorectal Cancer Among Disproportionately Affected Populations

2025-08-16

Abstract excerpt

Early-onset colorectal cancer (EOCRC; <50 years) incidence is increasing most rapidly among Hispanic/Latino (H/L) populations. While the transforming growth factor–beta (TGF-β) pathway influences colorectal cancer (CRC) progression, its prognostic role in FOLFOX-treated EOCRC, particularly in H/L patients, is unclear. We analyzed 2,515 CRC cases (H/L = 266; NHW = 2,249) stratified by ancestry, age at onset, and FO...

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Literature Corpus work
aad66fb3-d982-5ffc-a104-ae36c347a735
DOI
10.1101/2025.08.11.25333363
Open publication

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