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Integrating Artificial Intelligence and Precision Medicine to Characterize JAK-STAT Pathway Alterations in FOLFOX-Treated Colorectal Cancer in Disproportionately Affected Groups

2025-12-01

Abstract excerpt

Early-onset colorectal cancer (EOCRC) continues to rise, with the steepest increases observed among Hispanic/Latino (H/L) populations, underscoring the urgency of identifying ancestry- and treatment-specific biomarkers. The JAK-STAT signaling axis plays a central role in colorectal tumor biology, yet its relevance under FOLFOX-based chemotherapy in EOCRC remains poorly defined. In this study, we evaluated 2,515 co...

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Literature Corpus work
b272f017-3185-5493-9d83-3695f6624b94
DOI
10.1101/2025.11.27.25341180
Open publication

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