Article

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

2017-08-09

Abstract excerpt

Glioblastoma is characterized by widespread genetic and transcriptional heterogeneity, yet little is known about the role of the epigenome in glioblastoma disease progression. Here, we present genome-scale maps of the DNA methylation dynamics in matched primary and recurring glioblastoma tumors, based on a national population registry and a comprehensively annotated clinical cohort. We demonstrate the feasibility...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 409935ab-274f-522c-a938-77a8cb57ceec
DOI: 10.1101/173864

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and spaceDOI 10.1101/173864Read

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and spaceSemantic proximity Read

Molecular Neuropathology in Practice: Clinical Profiling and Integrative Analysis of Molecular Alterations in GlioblastomaSemantic proximity Read

Methylation subgroup and molecular heterogeneity is a hallmark of glioblastoma: implications for biopsy targeting, classification and therapySemantic proximity Read

Next Generation Sequencing and Machine Learning Technologies Are Painting the Epigenetic Portrait of GlioblastomaSemantic proximity Read

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamicsSemantic proximity Read

DNA methylation-based epigenetic signatures predict somatic genomic alterations in gliomasSemantic proximity Read

Multi‐omic integration of DNA methylation and gene expression data reveals molecular vulnerabilities in glioblastomaSemantic proximity Read

Longitudinal multimodal profiling of IDH-wildtype glioblastoma reveals the molecular evolution and cellular phenotypes underlying prognostically different treatment responsesSemantic proximity Read

Current status of DNA methylation profiling in neuro-oncology as a diagnostic support tool: A reviewSemantic proximity Read

Glioma Through the Looking GLASS: the Glioma Longitudinal Analysis consortium, molecular evolution of diffuse gliomasSemantic proximity Read

Epigenetics in human gliomas.Semantic proximity Read

Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis ConsortiumSemantic proximity Read