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Article

Intratumor heterogeneity in epigenetic patterns

31 Jan 2018

Abstract excerpt

Analogous to life on earth, tumor cells evolve through space and time and adapt to different micro-environmental conditions. As a result, tumors are composed of millions of genetically diversified cells at the time of diagnosis. Profiling these variants contributes to understanding tumors' clonal origins and might help to better understand response to therapy. However, even genetically homogenous cell populations...

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PMID: 29366906
DOI: 10.1016/j.semcancer.2018.01.010

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