Article
Live-cell NanoBRET assay to measure AKT inhibitor binding to conformational states of AKT
2025-03-20
Abstract excerpt
<h4>ABSTRACT</h4> AKT is the main protein kinase of the PI3K-AKT pathway, interacting with over one hundred protein partners to facilitate cellular processes that allow cancer cells to survive and proliferate. It is an attractive target due to its control over many cellular outputs. However, ATP-competitive and allosteric AKT inhibitors have performed poorly in clinical trials. AKT inhibitor interactions with AKT...
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Identifiers and source
- Literature Corpus work
- 3b080e25-e0db-554b-8fad-e0727748627c
- DOI
- 10.1101/2025.03.20.644015