Article
Catalytic mechanisms and regulation of protein kinases.
Methods in enzymology - 1 Jan 2014
Wang Zhihong, Cole Philip A
Abstract excerpt
Protein kinases transfer a phosphoryl group from ATP onto target proteins and play a critical role in signal transduction and other cellular processes. Here, we review the kinase kinetic and chemical mechanisms and their application in understanding kinase structure and function. Aberrant kinase activity has been implicated in many human diseases, in particular cancer. We highlight applications of technologies...
Topics
- Adenosine Triphosphate
- Animals
- Biocatalysis
- Humans
- Models, Molecular
- Mutation
- Phosphorylation
- Protein Conformation
- Protein Kinase Inhibitors
- Protein Kinases
- Protein Processing, Post-Translational
- Substrate Specificity