Article

Selective covalent-allosteric tools to dissect Akt2

2026-06-19

Abstract excerpt

The protein kinase Akt and its isoforms play a crucial role in various diseases. Unique functions of the individual isoforms (Akt1, Akt2, Akt3) might be essential for survival in malignancies. Particularly for Akt2, it was reported that a knock-out led to diabetic phenotype and might be correlated with clinically adverse hyperglycemic effects observed in pan Akt-treatment. Enduring failure of Akt inhibitors in the...

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Literature Corpus work: 999b0370-1891-57e4-b202-4aad1f965106
DOI: 10.64898/2026.06.15.732341

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