Article

Identification of a chemical probe for lipid kinase phosphatidylinositol-5-phosphate 4-kinase gamma (PI5P4Kγ)

2022-09-09

Abstract excerpt

<h4>ABSTRACT</h4> Phosphatidylinositol-5-phosphate 4-kinase gamma (PI5P4Kγ), which phosphorylates phosphatidylinositol-5-monophosphate (PI(5)P), is a human lipid kinase with intriguing roles in inflammation, T cell activation, autophagy regulation, immunity, heart failure, and several cancers. To provide a high-quality chemical tool that would enable additional characterization of this protein, we designed and ev...

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Literature Corpus work: 0bc5bc7c-3021-5fdc-aec4-da961c0b23cf
DOI: 10.1101/2022.09.08.507203

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