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Article

Engineering and Functional Analysis of Mitotic Kinases Through Chemical Genetics.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016

Jones Mathew J K, Jallepalli Prasad V

Abstract excerpt

During mitosis, multiple protein kinases transform the cytoskeleton and chromosomes into new and highly dynamic structures that mediate the faithful transmission of genetic information and cell division. However, the large number and strong conservation of mammalian kinases in general pose significant obstacles to interrogating them with small molecules, due to the difficulty in identifying and validating those...

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Identifiers

PMID: 27193860
DOI: 10.1007/978-1-4939-3542-0_22
PMCID: PMC6421128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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