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Article

The logic and design of analog-sensitive kinases and their small molecule inhibitors.

Methods in enzymology - 1 Jan 2014

Lopez Michael S, Kliegman Joseph I, Shokat Kevan M

Abstract excerpt

Analog-sensitive AS Kinase technology allows for rapid, reversible, and highly specific inhibition of individual engineered kinases in cells and in mouse models of human diseases. The technique consists of two parts: a kinase containing a space-creating mutation in the ATP-binding pocket and a bu...

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PMID: 25399647
DOI: 10.1016/B978-0-12-397918-6.00008-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25399647-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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