Nociceptor neurons impair cancer immunosurveillance

Abstract excerpt

<title>Abstract</title> <p>Solid tumors are innervated by nerve fibers that arise from the autonomic and sensory peripheral nervous systems. In prostate cancer, doublecortin-expressing neural progenitors initiate autonomic adrenergic neurogenesis1 which facilitates tumor development and dissemination2, via an angiogenic switch that fuels cancer growth3,4. Similarly, a loss of TP53 drives the reprogramming of tumo...

Topics

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• interferon and immune responses
• Mosquito-borne diseases and control
• Viral Infections and Vectors

Identifiers and source

Literature Corpus work

db4b0ca8-3b09-52ba-b824-7cff74dd42fb

DOI

10.21203/rs.3.rs-580730/v1