Article

Nociceptor neurons suppress antitumor immunity in breast cancer

2026-06-09

Abstract excerpt

<title>Abstract</title> <p>Peripheral nerves are emerging regulators of the tumor microenvironment, but how sensory innervation shapes breast cancer immunity remains poorly defined. Here we show that triple-negative breast cancers (TNBCs) co-opt nociceptor neurons to suppress antitumor immunity and promote disease progression. Across orthotopic TNBC models, we found that primary tumors and tumor-draining lymph no...

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Literature Corpus work: b5f0a120-86d4-58c1-bfa8-fac3fedc0a9f
DOI: 10.21203/rs.3.rs-9927184/v1

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