Article

Neuronal substance-P drives breast cancer growth and metastasis <i>via</i> an extracellular RNA-TLR7 axis

2024-03-11

Abstract excerpt

<h4>ABSTRACT</h4> Increased tumour innervation is associated with adverse survival outcomes in multiple cancers 1–4 . To better understand the mechanisms underlying this, we studied the impact of innervation on breast cancer metastatic progression. Metastatic mammary tumours of mice were substantially more innervated than non-metastatic isogenic tumours. Three dimensional co-cultures and in vivo models revealed...

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Literature Corpus work: 761fa6f9-af25-5c4c-b0b7-21b6d11a9fad
DOI: 10.1101/2024.03.08.584128

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