Article

Nociceptor neurons suppress antitumor immunity in breast cancer

2026-08-17

Abstract excerpt

<title>Abstract</title> <p>Peripheral nerves are emerging regulators of the tumor microenvironment, but how sensory innervation shapes breast cancer immunity remains poorly defined. Here we show that triple-negative breast cancers (TNBCs) co-opt nociceptor neurons to suppress antitumor immunity and promote disease progression. Across orthotopic TNBC models, we found that primary tumors and tumor-draining lymph no...

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Literature Corpus work: 0a7b9a33-cf20-5362-901d-dbff984654e2
DOI: 10.21203/rs.3.rs-9927184/v2

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