Article

Monocyte reprogramming by nociceptors impedes T cell-mediated tumor immunity

2026-01-16

Abstract excerpt

<h4>Summary</h4> Nociceptors – peripheral nervous system neurons that trigger the sensation of pain or itch in response to noxious stimuli – can communicate with leukocytes and modulate immune responses in a context-dependent manner 1,2 . Here, we demonstrate that nociceptors rapidly induce monocytes to adopt an immunosuppressive phenotype, reminiscent of myeloid-derived suppressor cells (MDSCs), which have been...

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Literature Corpus work: 646cbebb-98c1-5c13-b117-3914f1a134ad
DOI: 10.64898/2026.01.15.699724

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