Article

Quantifying intestinal stem cell dynamics using microsatellite sequencing

2017-01-01

Abstract excerpt

The intestinal epithelium is rapidly renewing throughout life. A population of stem cells exist within the intestinal crypt that drive rapid cell renewal and replace each other by a pattern of neutral drift. Perturbation of these dynamics through oncogenic mutation can predispose the epithelium to neoplastic transformation. Understanding the factors that govern these dynamics will give insight into the early stage...

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Literature Corpus work: db319a65-891f-50aa-ad88-fcc797582efb
DOI: 10.17863/cam.43233

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