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Article

Intestinal stem cell division and genetic diversity. A computer and experimental analysis.

The American journal of pathology - 1 Aug 1997

Tsao J L, Davis S D, Baker S M, Liskay R M, Shibata D

Abstract excerpt

Somatic mutations are expected to arise with age. This process is accelerated in mice lacking the DNA mismatch repair gene Pms2. The distributions of microsatellite alleles present in small patches of normal Pms2 -/- intestines revealed a general increase in genetic diversity or the number of mutations with age. However, the patterns were complex with different distributions and variances present within a single...

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Identifiers

PMID: 9250170
PMCID: PMC1857988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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