Intestinal stem cell division and genetic diversity. A computer and experimental analysis.

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Article

Intestinal stem cell division and genetic diversity. A computer and experimental analysis.

The American journal of pathology - 1 Aug 1997

Tsao J L, Davis S D, Baker S M, Liskay R M, Shibata D

Abstract excerpt

Somatic mutations are expected to arise with age. This process is accelerated in mice lacking the DNA mismatch repair gene Pms2. The distributions of microsatellite alleles present in small patches of normal Pms2 -/- intestines revealed a general increase in genetic diversity or the number of mut...

Topics

Adenosine Triphosphatases
Animals
Cell Death
Cell Division
Computer Simulation
DNA Repair Enzymes
DNA-Binding Proteins
Genetic Variation
Intestines
Mice
Mice, Knockout
Mismatch Repair Endonuclease PMS2
Models, Biological
Mutation
Proteins
Stem Cells

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Identifiers

PMID: 9250170
PMCID: PMC1857988

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9250170-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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