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Article

Quantification of crypt and stem cell evolution in the normal and neoplastic human colon.

Cell reports - 21 Aug 2014

Baker Ann-Marie, Cereser Biancastella, Melton Samuel, Fletcher Alexander G, Rodriguez-Justo Manuel, Tadrous Paul J, Humphries Adam, Elia George, McDonald Stuart A C, Wright Nicholas A, Simons Benjamin D, Jansen Marnix, Graham Trevor A

Abstract excerpt

Human intestinal stem cell and crypt dynamics remain poorly characterized because transgenic lineage-tracing methods are impractical in humans. Here, we have circumvented this problem by quantitatively using somatic mtDNA mutations to trace clonal lineages. By analyzing clonal imprints on the walls of colonic crypts, we show that human intestinal stem cells conform to one-dimensional neutral drift dynamics with a...

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Identifiers

PMID: 25127143
DOI: 10.1016/j.celrep.2014.07.019
PMCID: PMC4471679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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