Article
Diversity counts. Visualizing pretumor progression in the gastrointestinal tract.
American journal of clinical pathology - 1 Jun 2011
Langeveld Danielle, Jansen Marnix, Brosens Lodewijk, Morsink Folkert, Offerhaus G Johan, de Leng Wendy
Abstract excerpt
Tumor progression is critically dependent on the selection of genetic alterations. This clonal evolution can be traced to the stage preceding visible tumor formation called pretumor progression, in which genetic change occurs without visible change. Recently, the identification of intestinal stem cell markers in animal models has made visualization of stem cells possible in vivo. Translating this work to the...
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