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Article

Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes.

Nature genetics - 1 Mar 2021

Schwartzentruber Jeremy, Cooper Sarah, Liu Jimmy Z, Barrio-Hernandez Inigo, Bello Erica, Kumasaka Natsuhiko, Young Adam M H, Franklin Robin J M, Johnson Toby, Estrada Karol, Gaffney Daniel J, Beltrao Pedro, Bassett Andrew

Abstract excerpt

Genome-wide association studies have discovered numerous genomic loci associated with Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified. We performed an updated genome-wide AD meta-analysis, which identified 37 risk loci, including new associations near CCDC6, TSPAN14, NCK2 and SPRED2. Using three SNP-level fine-mapping methods, we identified 21 SNPs with >50% probability...

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Identifiers

PMID: 33589840
DOI: 10.1038/s41588-020-00776-w
PMCID: PMC7610386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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