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CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity.

Immunity - 19 Dec 2017

Suan Dan, Kräutler Nike J, Maag Jesper L V, Butt Danyal, Bourne Katherine, Hermes Jana R, Avery Danielle T, Young Clara, Statham Aaron, Elliott Michael, Dinger Marcel E, Basten Antony, Tangye Stuart G, Brink Robert

Abstract excerpt

Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC differentiation, no such marker exists for cells committed to the MBC lineage. Here, we report that the chemokine receptor CCR6 uniquely marks MBC precursors in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Positive Regulatory Domain I-Binding Factor 1

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Source

Identifiers

PMID: 29262350
DOI: 10.1016/j.immuni.2017.11.022

Genes

CCR6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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