Article

Shared and unique 3D genomic features of substance use disorders across multiple cell types

2024-07-19

Abstract excerpt

<h4>ABSTRACT</h4> Recent genome-wide association studies (GWAS) revealed shared genetic components among substance use disorders (SUDs). However, the extent of underlying shared causal variants, effector genes, and cellular contexts, remain unclear. We integrated 3D genomic datasets (high-resolution promoter-focused Capture-C/Hi-C, ATAC-seq, RNA-seq) from 59 diverse human cell types with recent GWAS summary statis...

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Literature Corpus work: 787529ab-c941-56b1-a503-2505fcdc969a
DOI: 10.1101/2024.07.18.24310649

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