Article

Crispr Cas9 fluorine-containing PEI nanomedicine inhibits the growth of hepatocellular carcinoma cells by knocking out NEDD8-E2 conjugase UBC12 (UBE2M)

2024-12-11

Abstract excerpt

<title>Abstract</title> <p>Knocking out the oncogene UBC12 with Crispr Cas9 can inhibit the Neddylation pathway and lead to excellent anticancer effect. However, how to deliver Crispr Cas9 into tumor cells is an urgent scientific problem. Based on the application of polyethyleneimine and its derivative (GMP in vivo-jetPEI) in clinical trials, we constructed fluorine-containing PEI to deliver Crispr Cas9 plasmid....

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Literature Corpus work: 6d2414d1-493d-5889-99e8-aee208e2ef78
DOI: 10.21203/rs.3.rs-5330067/v1

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Crispr Cas9 fluorine-containing PEI nanomedicine inhibits the growth of hepatocellular carcinoma cells by knocking out NEDD8-E2 conjugase UBC12 (UBE2M)DOI 10.21203/rs.3.rs-5330067/v1Read

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