Article
IgDesign: <i>In vitro</i> validated antibody design against multiple therapeutic antigens using inverse folding
2023-12-09
Abstract excerpt
Deep learning approaches have demonstrated the ability to design protein sequences given backbone structures [1, 2, 3, 4, 5]. While these approaches have been applied in silico to designing antibody complementarity-determining regions (CDRs), they have yet to be validated in vitro for designing antibody binders, which is the true measure of success for antibody design. Here we describe IgDesign , a deep learnin...
Topics
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- Biosimilars and Bioanalytical Methods
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Protein purification and stability
- Toxin Mechanisms and Immunotoxins
- Transgenic Plants and Applications
- vaccines and immunoinformatics approaches
- Viral Infectious Diseases and Gene Expression in Insects
Identifiers and source
- Literature Corpus work
- d755628f-9c81-54e4-a73b-efda95209637
- DOI
- 10.1101/2023.12.08.570889