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Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability

31 Jul 2024

Abstract excerpt

Designing effective monoclonal antibody (mAb) therapeutics faces a multi-parameter optimization challenge known as "developability", which reflects an antibody's ability to progress through development stages based on its physicochemical properties. While natural antibodies may provide valuable guidance for mAb selection, we lack a comprehensive understanding of natural developability parameter (DP) plasticity...

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PMID: 39085379
DOI: 10.1038/s42003-024-06561-3

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