Article

Unlocking <i>de novo</i> antibody design with generative artificial intelligence

2023-01-09

Abstract excerpt

Generative AI has the potential to redefine the process of therapeutic antibody discovery. In this report, we describe and validate deep generative models for the de novo design of antibodies against human epidermal growth factor receptor (HER2) without additional optimization. The models enabled an efficient workflow that combined in silico design methods with high-throughput experimental techniques to rapidly...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2803b691-d835-5336-a817-bd1cf6fa1f8c
DOI: 10.1101/2023.01.08.523187

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unlocking <i>de novo</i> antibody design with generative artificial intelligenceDOI 10.1101/2023.01.08.523187Read

A Generative Foundation Model for Antibody DesignSemantic proximity Read

IgGM: A Generative Model for Functional Antibody and Nanobody DesignSemantic proximity Read

A synergistic generative-ranking framework for tailored design of therapeutic single-domain antibodiesSemantic proximity Read

Designing Feature-Controlled Humanoid Antibody Discovery Libraries Using Generative Adversarial NetworksSemantic proximity Read

<i>De novo</i> design of hundreds of functional GPCR-targeting antibodies enabled by scaling test-time computeSemantic proximity Read

AB-Gen: Antibody Library Design with Generative Pre-trained Transformer and Deep Reinforcement LearningSemantic proximity Read

sdAbs-LLM: Generative Large Language Models For <i>de novo</i> Antibody Design and Agentic EvaluationSemantic proximity Read

Accelerating Antibody Design with Active LearningSemantic proximity Read

IgDesign: <i>In vitro</i> validated antibody design against multiple therapeutic antigens using inverse foldingSemantic proximity Read

p-IgGen: A Paired Antibody Generative Language ModelSemantic proximity Read

<i>In silico</i> design of stable single-domain antibodies with high affinitySemantic proximity Read

Hallucinating structure-conditioned antibody libraries for target-specific bindersSemantic proximity Read