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Article

Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232.

The Journal of experimental medicine - 14 Nov 2016

Xu Liling, Xia Mengdie, Guo Jun, Sun Xiaolin, Li Hua, Xu Chenguang, Gu Xiaomei, Zhang Haowen, Yi Junyang, Fang Yan, Xie Hengyi, Wang Jing, Shen Zhixun, Xue Boxin, Sun Yujie, Meckel Tobias, Chen Ying-Hua, Hu Zhibin, Li Zhanguo, Xu Chenqi, Gong Haipeng, Liu Wanli

Abstract excerpt

FcγRIIB functions to suppress the activation of immune cells. A single-nucleotide polymorphism in the transmembrane (TM) domain of FcγRIIB, FcγRIIB-T232, is associated with lupus. In this study, we investigated the pathogenic mechanism of FcγRIIB-T232 at both functional and structural levels. Our results showed that FcγRIIB-T232 exhibited significantly reduced lateral mobility compared with FcγRIIB-I232 and was...

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PMID: 27799621
DOI: 10.1084/jem.20160528
PMCID: PMC5110019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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