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Article

Fc γ receptor compositional heterogeneity: Considerations for immunotherapy development.

The Journal of biological chemistry - 1 Jan 2000

Barb Adam W

Abstract excerpt

The antibody-binding crystallizable fragment (Fc) γ receptors (FcγRs) are expressed by leukocytes and activate or suppress a cellular response once engaged with an antibody-coated target. Therapeutic mAbs that require FcγR binding for therapeutic efficacy are now frontline treatments for multiple diseases. However, substantially fewer development efforts are focused on the FcγRs, despite accounting for half of...

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Topics

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Share to Antibodies, Monoclonal
Share to Antigens, CD
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Fc Fragments

Share to Immunotherapy

Share to Killer Cells, Natural

Share to Receptors, Chimeric Antigen

Share to Receptors, IgG

Source

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Identifiers

PMID: 33172893
DOI: 10.1074/jbc.REV120.013168
PMCID: PMC7948983

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