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Article

Biophysical characterization of blood coagulation factor VIII binding to lipid nanodiscs that mimic activated platelet surfaces.

Journal of thrombosis and haemostasis : JTH - 1 Feb 2025

Avery Nathan G, Young Isabelle R, Lu Selena, Vaughan Jordan D, Korus Patrick S, Richardson Tera N, Childers Kenneth C, Smirnov Serge L, Spiegel P Clint

Abstract excerpt

BACKGROUND: Following proteolytic activation, activated blood coagulation factor (F)VIII (FVIIIa) binds to activated platelet membranes, forming the intrinsic tenase complex with activated FIX (FIXa). Previous studies have identified the C1 and C2 domains as the membrane binding domains of FVIII through conserved arginine residues. A membrane binding model for the FVIII C domains proposes that surface-exposed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39549835
DOI: 10.1016/j.jtha.2024.11.003
PMCID: PMC11786986

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C2

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