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Article

Genetic diversity affects the nanoscale membrane organization and signaling of natural killer cell receptors.

Science signaling - 17 Dec 2019

Kennedy Philippa R, Barthen Charlotte, Williamson David J, Pitkeathly William T E, Hazime Khodor S, Cumming Joshua, Stacey Kevin B, Hilton Hugo G, Carrington Mary, Parham Peter, Davis Daniel M

Abstract excerpt

Genetic diversity in human natural killer (NK) cell receptors is linked to resistance and susceptibility to many diseases. Here, we tested the effect of this diversity on the nanoscale organization of killer cell immunoglobulin-like receptors (KIRs). Using superresolution microscopy, we found that inhibitory KIRs encoded by different genes and alleles were organized differently at the surface of primary human NK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Killer Cells, Natural

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 6

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Source

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Identifiers

PMID: 31848320
DOI: 10.1126/scisignal.aaw9252
PMCID: PMC6944503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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