Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenome-wide association study of Alzheimer’s disease replicates 22 differentially methylated positions and 30 differentially methylated regions

17 Oct 2020

Abstract excerpt

Abstract Background Growing evidence shows that epigenetic modifications play a role in Alzheimer’s disease (AD). We performed an epigenome-wide association study (EWAS) to evaluate the DNA methylation differences using postmortem superior temporal gyrus (STG) and inferior frontal gyrus (IFG) samples. Results Samples from 72 AD patients and 62 age-matched cognitively normal controls were assayed using Illumina©...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Epigenetics and DNA Methylation
Share to Genetic Associations and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33069246
DOI: 10.1186/s13148-020-00944-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenome-wide association study of Alzheimer’s disease replicates 22 differentially methylated positions and 30 differentially methylated regionsPMID 33069246Read ↗

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology.Semantic proximity Read ↗

Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s diseaseSemantic proximity Read ↗

Early epigenetic changes of Alzheimer’s disease in the human hippocampusSemantic proximity Read ↗

DNA methylation signature of human hippocampus in Alzheimer’s disease is linked to neurogenesisSemantic proximity Read ↗

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s diseaseSemantic proximity Read ↗

Whole genome methylation sequencing in blood identifies extensive differential DNA methylation in late‐onset dementia due to Alzheimer's diseaseSemantic proximity Read ↗

Methylation differences in Alzheimer’s disease neuropathologic change in the aged human brainSemantic proximity Read ↗

<i>APOE</i>Genotype-specific Methylation Patterns are Linked to Alzheimer Disease Pathology and Estrogen ResponseSemantic proximity Read ↗

APOE genotype-specific methylation patterns are linked to Alzheimer disease pathology and estrogen response.Semantic proximity Read ↗

Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s diseaseSemantic proximity Read ↗

Fine‐mapping and replication of EWAS loci harboring putative epigenetic alterations associated with AD neuropathology in a large collection of human brain tissue samplesSemantic proximity Read ↗

An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.