Article

Paternal obesity alters the sperm epigenome and is associated with changes in the placental transcriptome and cellular composition

2022-08-31

Abstract excerpt

<h4>Summary</h4> Paternal obesity has been implicated in adult-onset metabolic disease in offspring. However, the molecular mechanisms driving these paternal effects and the developmental processes involved remain poorly understood. One underexplored possibility is the role of paternally driven gene expression in placenta function. To address this, we investigated paternal high-fat diet-induced obesity in relatio...

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Literature Corpus work: da9aabfc-7a5a-5624-a6a6-14b647596bd2
DOI: 10.1101/2022.08.30.503982

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